Originally a visita of Biñan, Sta. Rosa became a separate town, hacienda, and parish, notable for its wealth and development under Dominican control. The town was home to well-developed roads, irrigation systems, a large hacienda house, and fortifications near Silang, Cavite. Before becoming an independent parish, the barrio chapel was dedicated to Santo Domingo de Guzman, the founder of the Dominican Order. The first church, constructed in 1792 with wood, nipa, and “tabique pampango,” marked the founding of the town and parish, with Fr. Francisco Favie, OP, as the first parish priest. The present stone church's construction began in 1804 under Fr. Manuel de Mora, OP, using materials like adobe, bricks, limestone, and egg whites, with Chinese artisans who married local women contributing to its building over twelve years.

The church, still intact today, retains its original three retablos, doors, and bells. Over the centuries, the church underwent several architectural updates, including ceiling paintings by a local artist, renovations of side altars, and various structural changes. The feast day of St. Rose of Lima was traditionally celebrated on August 30, and the parish holds a cloth relic of the saint, acquired from the Diocese of Rome in 2005. In 1999, the Republic of Peru, through its Manila embassy, donated an image of Santa Rosa de Lima to the parish, which was accompanied by the construction of a new side retablo for the image, coinciding with the parish’s liturgical fiesta on August 23, 1999.

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